![]() ![]() A manual and electronic literature (MEDLINE, Cochrane Central Register of Controlled Trials, and Google Scholar) search was performed up to July 2013 for in vitro and in vivo studies and research presenting clinical, microbiological, immunological, and patient-centered data to validate the efficacy of Aloe vera To review composition, actions, and clinical applications of Aloe vera plant in dentistry and to establish its effectiveness as an invaluable adjunct in the treatment of dental diseases. The present work provides hint for those who prefer herbal formulations. Thus from the collected results, we concluded that the toothpaste containing a combination of Aloe and sodium chloride possesses antimicrobial activity, but for its practical use its necessary to determine its effect on oral cavities and probable side effects after its long tern use of its oral application as its future scope. The observed results were found to significant concerning the chosen cubic model in software Design Expert® 10. The formulation also shows sufficient foaming power for its cleansing action. At the end of work, we found that the prepared toothpaste shows considerable zone of inhibition which concludes its antimicrobial activity. After designing the batches in software Design Expert® 10, the batches were formulated and evaluated. In this formulation, we tried to find out the antimicrobial activity of Aloe vera in toothpaste formulation, for the said purpose we use S. Aloe vera shows a number of uses either internally or externally, and the number of uses also increases as the research going on. The formulation and evaluation of toothpaste contain Aloe vera along with the combination of sodium chloride.
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